A/N: THIS IS FOR SELF-DEFENSE ONLY!!! PLEASE DON'T USE THIS ON SOMEONE UNLESS YOU HAVE TO!!! THANK YOU!!!
Strategically speaking, the head is the best place to hit, but also the most difficult. The sharp bones of the skull makes it so that if you miss you could break or dislocate your fingers. If you don't want to risk it, go for the torso. It could damage on of the organs. Last, your opponent doesn't have to be unconscious for you to win. They could be dazed or not paying attention, effectively letting you get away.
Temple/jaw - Good for a knockout punch, but can be dangerous if you miss
Nose/eyes - Messes up the senses and distracts opponent
Neck - Can mess up breathing, talking and the spinal cord
Kicks are less effective here, also making it easier for your opponent to throw you off balance. Only use this if you know what you're doing.
Inner elbow - Can disable an opponent's arm
Solar plexus (Just below the diaphram) - Hard to hit but very effective
Liver - causes dizziness, immediate pain, and lose of breathe
Kidneys - I think we can all agree that peeing blood is unpleasant
Groin - ouch
Outer/Inner thighs - Have pressure points, and can buy you enough time to hit a better area
Knees - throws opponent off balance and permanently disables them
Update January 5, 2017 - It takes more energy to hit and miss than to actually hit them.
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Random Shit in my Head - Diary of a Problem Child 2016 (completed)
RandomThe title says it all Update January 5th, 2017 - The beginning is crap but it gets better at My Recurring Nightmare, so you can start there if you want. Also, the Reason Why I Was A Messed Up Kids is pretty good too.
